Abstract
N-3-Benzyloxycarbonylmethyl- and N-3-carboxymethyl-TBDMS-substituted nucleosides were synthesized and evaluated for activity against HIV replication. It was found that the N-3-carboxymethyl-TBDMS-substituted nucleosides were specific inhibitors of HIV-1 replication. They should be considered as members of a novel and original class of NNRTIs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Drug Evaluation, Preclinical
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HIV Reverse Transcriptase / antagonists & inhibitors*
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HIV-1 / drug effects
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HIV-2 / drug effects
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Humans
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Nucleosides / chemistry*
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Nucleosides / pharmacology*
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Organosilicon Compounds / chemistry
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Reverse Transcriptase Inhibitors / chemistry*
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Reverse Transcriptase Inhibitors / pharmacology*
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Structure-Activity Relationship
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Tumor Cells, Cultured / virology
Substances
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Nucleosides
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Organosilicon Compounds
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Reverse Transcriptase Inhibitors
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tert-butyldimethylsilyl chloride
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HIV Reverse Transcriptase